Summary

Pancreatic cancer generally expresses high level of PAUF (pancreatic adenocarcinoma upregulated factor), a protein that drives cancer cells to spread through blood flow and to escape immune recognition. PBP1510 specifically binds to PAUF and exerts anti-metastasis and immune modulation effects.

Mechanism of Action


Publication

[1] PAUF enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer. Oncotarget (2016).

[2] A PAUF-neutralizing antibody targets both carcinoma and endothelial cells to impede pancreatic tumor progression and metastasis. Biochem Biophys Res Commun (2014).

[3] PAUF, a novel endothelial activator, promotes angiogenesis and vascular permeability. Oncogene (2013).

[4] PAUF promotes metastasis by regulating TLR/CXCR4 activation. Oncogene (2011).

[5] PAUF, a novel up-regulated secretory protein in pancreatic ductal adenocarcinoma. Cancer Sci  (2009).